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The nanoparticle name itself implies a ‘Nano’ particle with size ranges from 1 nm to 100 nm [1], they can be classified into different classes based on their properties, shapes, or sizes. There are numerous ways available to synthesize metal nanoparticles, such as chemical, electrochemical, and radiation methods. However, chemical processes often produce toxic chemicals that may result in undesirables’ secondary effects in medical applications. Green chemistry is a better solution as it can decrease or remove the use of hazardous substances. The current trend is to synthesize nanomaterials using aqueous extracts of medicinal plants due to their eco-friendly nature and cost-effectiveness [2].
In the present study, we synthesized silver (Ag) nanoparticles using an aqueous extract of Pulicaria odora roots and then estimated their antibacterial activity against five bacteria at different concentrations. Two parameters were considered for nanoparticle synthesis: AgNO3 concentrations (1, 5, and 10 mM) and aqueous extract concentrations of P. odora (25, 50, 100, and 200 ppm). According to SEAD results and analysis of TEM, the obtained nanoparticles have spherical shapes and sizes between 10 to 75 nm.
Results showed that the nanoparticles 10mM exhibited significant antibacterial activity. In fact, a potent antibacterial activity was observed against Escherichia coli BLSE, Klebsiella pneumonia, and Acinetobacter baumannii. The activity of nanoparticles was similar to or higher than those of the standard antibiotics. These results suggest that silver nanoparticles synthesis using P. odora aqueous extract can be used as an effective growth inhibitor of various microorganisms, making them applicable to diverse medical devices and antimicrobial control systems.
