Speaker
Description
The present study was carried out to evaluate the genotoxic effects of bioactive compounds of some selected Moroccan honeys in Vicia faba roots. The potential anti-genotoxic effect of honey extract against cyclophosphamide (CP)-induced cytotoxicity and genotoxicity were also assessed. This research was carried out in two stages. In the first stages, the exposure of Vicia faba plants to two to three concentrations of the phenolic extract of honey showed no significant differences in genotoxic and cytotoxic effects between the concentrations of the eight honey extracts (P value > 0.05). The determination of the genotoxic effect of the different treatments in comparison with CP shows essentially that the Fennel honey extract has the highest genotoxic effect in comparison with the other treatments with a genotoxic effect value of 64.36 ± 20.96 %. In the second stage, interactions between two concentrations of each type of honey extract (1 mg/mL and 0.1 mg/mL) and CP were used to test the effects of honey extracts on CP-induced toxicity. The results indicated that, especially for Thyme honey at the concentration of 0.1 mg/mL, a low micronucleus frequency and a high anticlastogenic efficacy in comparison with the genotoxic actions of CP only. These results show the potential beneficial effect of honey extract to attenuate the side effects of CP-chemotherapy.
