SMACUMED International Conference on Water-Energy-Food-Ecosystem Nexus in the Mediterranean Region (WEFE 2023)

In vivo evaluation of antivenom activity of Adenocarpus anagyrifolius methanolic extract against Hottentotta gentili scorpion venom

Nov 15, 2023, 3:40 PM

10m

The Mohamed VI Museum of Water Civilization (Marrakesh, Morocco)

Oral presentation - in person Food Food Security & Food Safety and Toxicology

Speaker

Karima Benrazzouk (Laboratory of Agri-Food, Biotechnology, and Valorization of Plant Resources; Phytochemistry and Pharmacology of Medicinal Plants Unit, Faculty of Sciences Semlalia, Cadi Ayyad University, Marrakech, Morocco;)

Description

The effectiveness of the methanolic extract from the aerial parts of Adenocarpus anagyrifolius in countering the venom of Hottentotta gentili was assessed through oral administration at doses of 100, 150, and 200mg/kg following the subcutaneous injection of a venom dosage lethal to 99% of the test subjects (LD99). The findings revealed a remarkably successful outcome, as the mice survived even after 24 hours. Furthermore, when LD50 and a dose of 200 mg/kg were administered, there was a noticeable reversal of damage in various tissues and a significant reduction in the levels of biochemical markers. The potent antioxidant activity, coupled with the presence of active metabolites, offers a plausible explanation for the potential of A. anagyrifolius as a natural product candidate for drug development.