Speaker
Description
Mycotoxins are secondary metabolites that are produced by a range of fungi. These compounds are responsible for mycotoxicosis, a potentially deadly condition with significant health consequences. The severity of the effects of mycotoxins is influenced by various factors, including the specific toxicity of the toxin, the level of exposure, the age and nutritional status of the affected individual, and any potential interactions with other chemicals. Exposure to mycotoxins can occur through ingestion, inhalation, dermal contact, or breastfeeding. Ochratoxin A (OTA), a well-documented mycotoxin, is a key fungal metabolite produced by Penicillium verrucosum and Aspergillus ochraceus, and it is recognized for its harmful effects on health, particularly its ability to cause significant renal damage. Extensive research has demonstrated OTA’s neurotoxic properties in both in vivo and in vitro models. In our study, we observed a pronounced neurotoxic impact of OTA on the developing mouse brain, with exposure to 0.25 mg/kg on day 10 of gestation. The neurotoxic effects persisted through early postnatal development into adulthood, with notable impairments in neurobehavioral functions, particularly in memory, mood, and motor coordination. These effects were accompanied by severe morphological damage to key organs such as the kidneys and liver. Furthermore, oxidative stress biomarkers were quantified, providing additional evidence supporting the neurotoxic role of OTA. In summary, our findings reinforce the significant neurotoxic effects of OTA, emphasizing its potential harm to the developing brain.
Keywords
Behavioral tests - Developmental - Mycotoxins – Mice - Neurotoxicity - Ochratoxin A
