Speaker
Description
In the context of global climate change and the urgent need for sustainable public health solutions, the valorization of local medicinal plants offers a promising approach combining biodiversity, traditional knowledge, and green pharmacology. Dysphania ambrosioides, traditionally used in Moroccan medicine to treat inflammatory conditions, is gaining scientific interest as a natural source of bioactive compounds [1].
This study aimed to evaluate the anti-inflammatory activity of dichloromethane (DCM) and methanolic (MeOH) extracts of Dysphania ambrosioides using both in vivo [2] and in vitro models [3,4]. In the carrageenan-induced paw edema model in mice, the DCM extract showed 62.99% inhibition at 100 mg/kg and 54.14% at 300 mg/kg, while the MeOH extract achieved 59.21% and 63.43% inhibition at the same doses after four hours. In vitro assays based on protein denaturation (egg albumin and bovine serum albumin) further confirmed these results. The MeOH extract exhibited 73.60% inhibition of egg albumin denaturation (compared to 69.12% for diclofenac sodium) and 92.53% inhibition of BSA denaturation (vs. 96.47% for diclofenac), while the DCM extract remained moderately active (60.33% and 59.9%, respectively).
These findings support the traditional use of Dysphania ambrosioides and highlight its potential as a natural anti-inflammatory agent. Its valorization contributes to the development of accessible, environmentally friendly therapeutic alternatives based on local natural resources, strengthening health resilience in the face of climate and ecological challenges. Further studies are warranted to isolate the active constituents and elucidate their mechanisms of action.
Keywords: Dysphania ambrosioides, plant bioactives, anti-inflammatory, methanolic extract, dichloromethane extract, natural resources, biodiversity, public health.
